| Sanctum Outskirts Watch Treasure StorageQuest Instance | Quest Instance | — | — |
| Sand Dunes HideoutQuest Instance | Quest Instance | — | — |
| Sandstorm TempleBattlefield | Battlefield | — | — |
| Scale AltarSealed Dungeon | Sealed Dungeon | — | — |
| Scarlotus Experiment SiteQuest Instance | Quest Instance | — | — |
| Scout Bagsh's Recon SiteInstance Layer | Instance Layer | — | — |
| Scout Sahar's Recon SiteInstance Layer | Instance Layer | — | — |
| Scribe's RoomSealed Dungeon | Sealed Dungeon | — | — |
| Searcher Sudka's Recon SiteInstance Layer | Instance Layer | — | — |
| Secluded StorageQuest Instance | Quest Instance | — | — |
| Second StageQuest Instance | Quest Instance | — | — |
| Sehna OutpostInstance Layer | Instance Layer | — | — |
| Sehna Outpost Treasure StorageQuest Instance | Quest Instance | — | — |
| Shaded CaveQuest Instance | Quest Instance | — | — |
| Shulak CaveSealed Dungeon | Sealed Dungeon | — | — |
| Shuttered WorkstationInstance Layer | Instance Layer | — | — |
| Sigebert's AbyssAscension Story | Ascension Story | — | — |
| Skurv Laborer DenSealed Dungeon | Sealed Dungeon | — | — |
| Slayer Kroms' Recon SiteInstance Layer | Instance Layer | — | — |
| Slumbering Frozen Lake CaveQuest Instance | Quest Instance | — | — |
| Small HouseInstance Layer | Instance Layer | — | — |
| Smuggler's CaveSealed Dungeon | Sealed Dungeon | — | — |
| Solitary Rock TombSealed Dungeon | Sealed Dungeon | — | — |
| South of Verteron Fortress RuinsInstance Layer | Instance Layer | — | — |
| Spider CaveSealed Dungeon | Sealed Dungeon | — | — |
| Spirit Flower CaveSealed Dungeon | Sealed Dungeon | — | — |
| Spirit TempleQuest Instance | Quest Instance | — | — |
| Stormslumber SnowfieldBattlefield | Battlefield | — | — |
| Subspace of AscensionAscension Story | Ascension Story | — | — |
| Sunken Ancient LegacySealed Dungeon | Sealed Dungeon | — | — |
| Sunken TempleSealed Dungeon | Sealed Dungeon | — | — |
| Supply Depot Interior BaseInstance Layer | Instance Layer | — | — |
| Surana RefineryQuest Instance | Quest Instance | — | — |
| Suspicious CaveQuest Instance | Quest Instance | — | — |
| Targoth's CaveSealed Dungeon | Sealed Dungeon | — | — |
| Tarzel DepositoryQuest Instance | Quest Instance | — | — |
| Tayga Breeding GroundSealed Dungeon | Sealed Dungeon | — | — |
| Temporary ClinicInstance Layer | Instance Layer | — | — |
| Torturer Tregon's Recon SiteInstance Layer | Instance Layer | — | — |
| Tracker Dazran's Recon SiteInstance Layer | Instance Layer | — | — |